Oh Erika, I am SO sorry that your friend has this mindset.
It is hard to see someone you like setting off down a path that may ultimately lead them into ICU.
One cannot reason with these people, and I think that you are right, more and more places will insist on proof of vaccination to get in/work/whatever and eventually this will excvlude the antivaxers completely.
Here in Canada, the debate is raging about the need to provide proof of vaccination/vs not. Politicians are terrified to take action sine votes may lag if they make the wrong choice.